Tag: amitriptyline

Tricyclic Antidepressants and Antihistamines: The Hidden Danger of Anticholinergic Overload

Tricyclic Antidepressants and Antihistamines: The Hidden Danger of Anticholinergic Overload

Combining tricyclic antidepressants like amitriptyline with antihistamines like Benadryl can cause dangerous anticholinergic overload, increasing risks of confusion, delirium, and dementia - especially in older adults. Learn how to spot and avoid this hidden drug interaction.

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